Cancer represents a formidable current and future global health challenge. The LUMC Medical Research Profile Cancer Pathogenesis and Therapy has the mission to meet this challenge by developing and implementing innovative patient-tailored, multimodal diagnostic methods and treatment modalities. Our multidisciplinary approach aims to integrate and to translate excellent results of basic research in cancer genetics, molecular cell biology, and immunology into precision cancer care. Besides common cancer types, the translational research efforts focus in particular on selected tumor types for which the LUMC represents a national and international referral center.